Selank has a range of neuro-biochemical actions and combines many benefits associated with the use of antidepressants and psychostimulants, such as activation of the brain monoaminergic systems, dopamine synthesis and modulation of the tyrosine hydroxylase activity.
The peptide has been shown to increase serotonin levels, dopamine synthesis and dopamine metabolites in rat brain to produce anti-anxiety effects
Selank is a synthetic analogue of the immunomodulatory peptide tuftsin; as such, it mimics many of its effects. It has been shown to modulate the expression of Interleukin-6 (IL-6) and affect the balance of T helper cell cytokines. It has been shown to influence the concentration of monoamine neurotransmitters and induce metabolism of serotonin. Selank has also been found to rapidly elevate the expression of brain-derived neurotropic factor (BDNF) in the hippocampus of rats.
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