ACE-083 is an investigational protein therapeutic that has been designed for local administration to increase muscle mass and strength in specific muscles and muscle groups. Acceleron is developing ACE-083 for diseases in which improved muscle strength may provide a clinical benefit, such as inclusion body myositis and certain forms of muscular dystrophy.

Select proteins in the TGF-β protein superfamily normally function to modulate muscle growth. ACE-083 has been designed to block those proteins and, in doing so, can increase muscle mass and strength. ACE-083 has been engineered to exert this action only within the muscle or muscle group treated. In preclinical animal studies, ACE-083 has shown selective and dose-dependent increases in muscle mass in treated muscles with no effects in untreated muscles.

This product is intended for research and medical purposes only, to be only used by trained professionals.

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Research use only. Not for human or animal consumption.

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