The newish supplement to be used by Bodybuilders are Peptides that naturally pulse GH from the body, the problem is that many make it all to confusing much more than it needs to be so i thought it would be a good article to write to try and clear some of the confusion on the subject.

if you prefer the science and long boring words to describe things this article is not for you so here is a very basic guide, it does not contain any real detail to the science behind the need etc……

you need to look at 2 types of peptides:
GHRP – this group’s main types are GHRP-2, GHRP-6, Ipamorelin, Hexarelin (there are others but these are the most common and effective)
GHRH – this groups main type is Mod GRF 1-29 (sometimes called CJC1295 without DAC)

What do they do:
They release and amplify a natural pulse of GH from your body
GHRP release a pulse of GH
GHRH release and amplify this pulse
Combining both peptides gives more than double the effect of either alone due to the synergy they have it would be foolish in my opinion to use either alone.

GHRP-6 DESCRIPTION

GHRP-6 peptide (Growth hormone-releasing peptide-6) is synthetic analogue of endogenous opioid peptide met-enkephalin, includes unnatural D-amino acids, and belongs to the growth hormone secretagogues group and its ghrelin receptor agonists subgroup. Growth hormone secretagogues (GHS) lack opioid activity but are powerful stimulants of growth hormone production. Simultaneously GHS are distinct from growth hormone releasing hormone (GHRH) in that they share no sequence relation and derive their function through activation of a completely different receptor – growth hormone secretagogue receptor (GHSR; or often called simple as ghrelin receptor). Natural endogenous ligand of Growth hormone secretagogue receptors is endogenous hormone Ghrelin. All ghrelin receptor agonists (incl. GHRP-6 peptide) act as synthetic ghrelin mimetics. GHRP-6 peptide is structurally very similar to its predecessor GHRP-2 peptide.

GHRELIN 

Ghrelin (often called also as a “hunger hormone”) is endogenous hormone produced by enteroendocrine cells of the gastrointestinal tract, especially the stomach. Blood levels of ghrelin are highest before meals when hungry, and low after mealtimes. Ghrelin helps prepare for food intake by increasing gastric motility and gastric acid secretion. But Ghrelin also activates cells in the anterior pituitary gland and hypothalamic arcuate nucleus (including neuropeptide Y neurons that initiate appetite). Ghrelin binds to specific receptor – the growth hormone secretagogue receptor 1A (GHSR-1A), and stimulate GH secretion, but also is involved in other important functions – regulation of reward cognition, learning and memory, the sleep-wake cycle, taste sensation, reward behavior, and glucose metabolism.

GROWTH HORMONE SECRETAGOGUE RECEPTOR

The ghrelin receptor GHSR-1A (a splice-variant of the growth hormone secretagogue receptor, with the GHS-R1b splice being inactive) is involved in mediating a wide variety of biological effects of ghrelin, such as: stimulation of growth hormone release, increase in hunger, modulation of glucose and lipid metabolism, regulation of gastrointestinal motility and secretion, protection of neuronal and cardiovascular cells, and regulation of immune function. They are present in high density in the hypothalamus and pituitary, on the vagus nerve (on both afferent cell bodies and efferent nerve endings) and throughout the gastrointestinal tract.

GHRP-6 RESULTS OF ACTION

GHRP-6 is highly effective in increasing blood levels of HGH and IGF-1. Due to its properties, it is a promising candidate for the treatment of growth hormone deficiency, cachexia (wasting), eating disorders and obesity. Early studies translated into a new research era that inserted synthetic GHRPs also as promising cardio and cytoprotective candidates. A broad safety profile and a successful preclinical pharmacology nurtured the enthusiasm for GHRP-6 as a myocardial reperfusion damages-attenuating candidate. The existence of efficacious although occasional and fragmented clinical interventions in life-threatening conditions, along with the GHRP-6 multifactorial mechanism of action in myocardial infarction, ignite the initiative for a coherent clinical development. 

GHRP-6:
Growth hormone releasing peptide-6 (GHRP-6) is in the category of drugs known as GH Secretagogues. This category of drugs includes GHRP-2, GHRP-6, Ipamorelin, and Hexarelin. Their primary function is to stimulate the pituitary gland to produce more Growth Hormone. GHRPs have a 2-fold mechanism of action, in that they cause an increase in GH through amplifying the natural growth hormone releasing hormone (GHRH) signal transduction pathway, as well as by suppressing the actions of somatostatin.
GHRP-6 is a 1st generation GHRP and is primarily used in the BB’ing community for two reasons, which are 1) GH release and 2) Appetite stimulation. If one is considering using this peptide for GH release, the individual should consider whether or not the accompanying appetite stimulation is a beneficial or negative characteristic in their current circumstances. In individuals who struggle with appetite issues and have trouble eating enough food to meet their daily caloric requirements, this peptide can prove to be a great addition to their program. For those on contest diets or who are trying to lean out, they may want to forego this peptide in exchange for a GHRP absent of this effect.

Common benefits of GH (GHRP-6) include:

* Reductions in body fat
* Increased lean mass.
* Increased collagen production
* Improved sleep
* Increased cellular repair
* An increase in IGF-1
* Increases in bone density

Common side effects of GH (GHRP-6) include:

* Water retention
* Tightness and/or carpel tunnel-like symptoms in the wrist/hand.
* Numbness and tingling in the extremities
* A decrease in insulin sensitivity
* Tiredness

Recommendations for use:

* GHRP-6 should be administered on an empty stomach. No food should be consumed for 15-20 minutes post-inject, if maximum GH release is desired.
* When using GHRP-6 for GH release, the average dosing range is between 100-150 mcg per inject. Dosing frequency is between 1-4X per day.
* In order to elicit maximal elevations in GH, GHRP-6 should be combined with a GHRH, such as ModGRF1-29 (also known as CJC1295 w/o dac).
* If used for appetite stimulation, the common dosing range for GHRP-6 is between 100-300 per inject, as needed.

GHRP-2:

Growth hormone releasing peptide-2 (GHRP-2) is in the category of drugs known as GH secretagogues. This category of drugs includes GHRP-2, GHRP-6, Ipamorelin, and Hexarelin. Their primary function is to stimulate the pituitary gland to produce more growth hormone. GHRPs have a 2-fold mechanism of action, in that they cause an increase in GH through amplifying the natural growth hormone releasing hormone (GHRH) signal transduction pathway, as well as by suppressing the actions of somatostatin.

GHRP-2 is a 2nd generation GHRP and finds its primary use in the area of GH release. It is superior to GHRP-6 in this regard and is currently the preferred peptide for attaining maximum elevations in GH over the long-term. Recent research also reveals that GHRP-2 can be dosed much higher than initially thought, while avoiding the desensitization that is inherent in some of our other GHRP’s. This provides the user with the opportunity to experience greater elevations in total GH, depending on the dosage administered. Lastly, while GHRP-2 can potentially lead to some degree appetite stimulation, not all users experience this effect and when they do, it is typically much less profound in comparison to GHRP-6.

Common benefits of GH (GHRP-2) include:

* Decreases in body fat
* An increase in lean mass
* Increased collagen production
* Improved sleep
* Increased cellular repair
* An increase in IGF-1
* Increases in bone density

Common side effects of GH (GHRP-2) include:

* Water retention
* Tightness and/or carpel tunnel-like symptoms
* Numbness and tingling in the extremities
* A decrease insulin sensitivity
* Tiredness